associations between hyperuricemia and chronic kidney disease: a review
نویسندگان
چکیده
context in human beings, uric acid is the poorly soluble circulating end product of the purine nucleotide metabolism. a reduction in the glomerular filtration rate (gfr) contributes to hyperuricemia, which is frequently observed in patients with chronic kidney disease (ckd). evidence acquisition hyperuricemia is defined as a serum uric acid level > 7.0 mg/dl in males and > 6.0 mg/dl in females, while ckd is defined as kidney damage or a gfr < 60 ml/min/1.73 m2 for 3 months or more, irrespective of the cause. hyperuricemia is common in ckd and may occur because of decreased excretion, increased production, or a combination of both mechanisms. results the causes for hyperuricemia in overproducers may be either exogenous or endogenous. ckd has become a global public health problem because of its high prevalence and the accompanying increase in the risk of end-stage renal disease, cardiovascular disease, and premature death. the most common risk factors for ckd are obesity and the metabolic syndrome, which is strongly associated with hyperuricemia probably as a consequence of insulin resistance and the effects of insulin to reduce the urinary urate excretion. for recurring bouts of hyperuricemia or gout, patients should have a blood test and joint fluid test to determine whether the medication taken is effective. interventional studies are a useful clinical research tool in clarifying the role of hyperuricemia in ckd. conclusions although many evidence-based studies have suggested that uric acid itself may harm patients with ckd by increasing inflammation and ckd progression, the issue is still a matter of controversy. special attention should be paid to specific contraindications to certain drugs and the possibility of infectious arthritis.
منابع مشابه
Associations Between Hyperuricemia and Chronic Kidney Disease: A Review
CONTEXT In human beings, uric acid is the poorly soluble circulating end product of the purine nucleotide metabolism. A reduction in the glomerular filtration rate (GFR) contributes to hyperuricemia, which is frequently observed in patients with chronic kidney disease (CKD). EVIDENCE ACQUISITION Hyperuricemia is defined as a serum uric acid level > 7.0 mg/dL in males and > 6.0 mg/dL in female...
متن کاملAsymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial
Today there is plausible evidence both on experimental and epidemiological basis, that hyperuricemia represents a risk factor for the development and progression of chronic kidney disease (CKD). Nevertheless, the role of serum uric acid lowering treatment in CKD is still a matter of serious controversy. Review of randomised controlled trials, suggests that there may be an improvement of renal f...
متن کاملFebuxostat for Hyperuricemia in Patients with Advanced Chronic Kidney Disease
Febuxostat is a nonpurine xanthine oxidase (XO) inhibitor, which recently received marketing approval. However, information regarding the experience with this agent among advanced chronic kidney disease (CKD) patients is limited. In the current study, we investigated the effects of oral febuxostat in patients with advanced CKD with asymptomatic hyperuricemia. We demonstrated, for the first time...
متن کاملNutritional Status of Patients with Chronic Kidney Disease in Iran: A Narrative Review
Background: Chronic kidney disease (CKD) is a progressive condition that affects many aspects of patient’s life with adverse outcomes of kidney failure, cardiovascular disease (CVD), and premature death. Malnutrition is a relatively common problem in these patients that may be the result of inadequate intake, increased catabolism, or loss of nutrients in the dialysis. The aim of this study was ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
nephro-urology monthlyجلد ۷، شماره ۳، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023